An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases

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Updated May 7, 2025

Among multifactorial diseases, there are many diseases involving the immune system (e.g., autoimmune diseases, allergic diseases, infectious diseases, cancer, and transplantation) for which there are few appropriate treatments. In order to solve these problems and find better treatments, we believe that a thorough understanding of human immune functions and an appropriate understanding of pathological conditions in these diseases are necessary. Therefore, this study aims to establish a new methodology for disease research based on omics analyses and geneticpolymorphism analysis of immune cells such as lymphocytes derived from healthy individuals, and to accumulate important information for understanding pathological conditions and determining targets for drug discovery.

Yasuhiro MurakawaRIKENyasuhiro.murakawa@riken.jp

An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases (Official HCA Publication)

Akiko Oguchi1
Akari Suzuki1
Shuichiro Komatsu1
Chikashi Terao1
Kazuhiko Yamamoto1
Yasuhiro Murakawa1
1RIKEN
Ida Zucchi

To reference this project, please use the following link:

https://explore.data.humancellatlas.org/projects/08c7910b-5ebb-4dfc-a866-5bf392ef3b36
None
None

Atlas

None

Analysis Portals

None

Project Label

CD4EnhancerProject

Species

Homo sapiens

Sample Type

specimens

Anatomical Entity

blood

Organ Part

Unspecified

Selected Cell Types

Unspecified

Disease Status (Specimen)

normal

Disease Status (Donor)

normal

Development Stage

human adult stage

Library Construction Method

5 library construction methods

Nucleic Acid Source

2 nucleic acid sources

Paired End

true

Analysis Protocol

CellRanger_analysis, CellRanger_arc_analysis, Seurat_analysis

File Format

3 file formats

Cell Count Estimate

353.0k

Donor Count

3
fastq.gz444 file(s)rds7 file(s)xlsx1 file(s)
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