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Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

Access Granted
Updated May 24, 2022

The goals of this study were to identify cell specific expression patterns of the retinal pigment epithelium (RPE) and a variety of choroidal cell types originating from the macula and the periphery of human donor eyes, with a particular emphasis on identifying expression signatures of choroidal endothelial cells.

Todd ScheetzUniversity of Iowa, Iowa Citytodd-scheetz@uiowa.edu
Todd Scheetz (Principal Investigator)1
1University of Iowa, Iowa City
Parisa Nejad
Rachel Schwartz
Brittney D Wick

To reference this project, please use the following link:

https://explore.data.humancellatlas.org/projects/7880637a-35a1-4047-b422-b5eac2a2a358
None
GEO Series Accessions:
GSE135922

Downloaded and exported data is governed by the HCA Data Release Policy and licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). For more information please see our Data Use Agreement.

Atlas

None

Analysis Portals

CZ CELLxGENECZ CELLxGENE
UCSC Cell BrowserUCSC Cell Browser

Project Label

HumanRPEandChoroid

Species

Homo sapiens

Sample Type

specimens

Anatomical Entity

eye

Organ Part

2 organ parts

Selected Cell Types

choroidal cell of the eye

Disease Status (Specimen)

3 disease statuses

Disease Status (Donor)

3 disease statuses

Development Stage

human adult stage

Library Construction Method

10x v3 sequencing

Nucleic Acid Source

single cell

Paired End

false

Analysis Protocol

analysis_protocol_1, analysis_protocol_2

File Format

2 file formats

Cell Count Estimate

18.6k

Donor Count

7
fastq.gz352 file(s)tsv.gz14 file(s)