Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Access Granted
Updated February 14, 2025

Single-cell RNA-seq analysis of primary and metastatic (liver) human PDAC tumors, some pre-treatment and some post-chemotherapy. (Please note that although the file has "RAW" in the name these are the filtered results from CellRanger.) Overall design: Single-cell RNA-seq analysis of primary and metastatic (liver) human PDAC tumors, some pre-treatment and some post-chemotherapy

Aristotelis TsirigosNYU Langone HealthAristotelis.Tsirigos@nyulangone.org
Diane M SimeonNYU Langone HealthDiane.Simeone@nyulangone.org
Gregor Werba1
Daniel Weissinger1
Emily A Kawaler1
Ende Zhao1
Despoina Kalfakakou1
Surajit Dhara1
Lidong Wang1
Heather B Lim1
Grace Oh1
Xiaohong Jing1
Nina Beri1
Lauren Khanna1
Tamas Gonda1
Paul Oberstein1
Cristina Hajdu1
Cynthia Loomis1
Adriana Heguy1
Mara H Sherman2
Amanda W Lund1
Theodore H Welling1
Igor Dolgalev1
Aristotelis Tsirigos1
Diane M Simeon1
1NYU Langone Health
2Oregon Health Sciences University
Anu Shivalikanjli

To reference this project, please use the following link:

https://explore.data.humancellatlas.org/projects/7f9766ff-bb12-4279-b340-78d140bdd7ba
None
INSDC Project Accessions:
GEO Series Accessions:
INSDC Study Accessions:

Atlas

None

Analysis Portals

None

Project Label

Tsirigos_10x_pdac

Species

Homo sapiens

Sample Type

specimens

Anatomical Entity

2 anatomical entities

Organ Part

Unspecified

Selected Cell Types

Unspecified

Disease Status (Specimen)

pancreatic ductal adenocarcinoma

Disease Status (Donor)

pancreatic ductal adenocarcinoma

Development Stage

human adult stage

Library Construction Method

2 library construction methods

Nucleic Acid Source

single cell

Paired End

false

Analysis Protocol

analysis_raw

File Format

4 file formats

Cell Count Estimate

139.4k

Donor Count

27
fastq.gz140 file(s)mtx.gz27 file(s)tsv.gz54 file(s)xlsx1 file(s)
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