Single-Cell Transcriptomics of the Human Endocrine Pancreas
We successfully sequenced and annotated more than 400 cells from child, adult control, type 1 diabetes and type 2 diabetes donors. We detect donor-type specific transcript variation. We also report that cells from child donors have less defined gene signature. Cells from type 2 diabetes donors resemble juvenile cells in gene expression.
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Atlas
Pancreas v1.0Analysis Portals
NoneProject Label
HumanEndocrinePancreasSpecies
Homo sapiens
Sample Type
specimens
Anatomical Entity
pancreas
Organ Part
islet of Langerhans
Selected Cell Types
pancreatic endocrine cell
Disease Status (Specimen)
Disease Status (Donor)
Development Stage
Library Construction Method
Smart-seq2
Nucleic Acid Source
single cell
Paired End
falseAnalysis Protocol
MultiSampleSmartSeq2_v2.2.6, SmartSeq2SingleSample_v5.1.5File Format
Cell Count Estimate
635Donor Count
8