Single-cell RNA Sequencing of human microglia from post mortem Alzheimers Disease CNS tissue.

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Updated February 14, 2025

The transcriptomes of microglia were investigated at a single cell level in non-demented elderly and Alzheimers Disease donors using acute human post-mortem cortical brain samples.

Bart JL EggenUniversity of Groningen, University Medical Center Groningenb.j.l.eggen@umcg.nl
Astrid M Alsema1
Qiong Jiang1
Laura Kracht1
Emma Gerrits1
Marissa L Dubbelaar1
Anneke Miedema1
Nieske Brouwer1
Elly M Hol2
Jinte Middeldorp2
Roland van Dijk2
Maya Woodbury3
Astrid Wachter4
Simon Xi3
Thomas Möller4
Knut P Biber5
Susanne M Kooistra1
Erik WGM Boddeke1
Bart JL Eggen1
1University of Groningen, University Medical Center Groningen
2University Medical Centre Utrecht, University Utrecht
3Foundational Neuroscience Center, AbbVie Inc.
4Neuroscience Discovery, AbbVie Deutschland GmbH and Co. KG
5Neuroscience Discovery, AbbVie Deutschland GmbH and Co. KG, Ludwigshafen, Germany.
Ami Day

To reference this project, please use the following link:

https://explore.data.humancellatlas.org/projects/b51f49b4-0d2e-4cbd-bbd5-04cd171fc2fa
None
INSDC Project Accessions:
GEO Series Accessions:
INSDC Study Accessions:

Atlas

None

Analysis Portals

None

Project Label

SingleCellsAlzheimers

Species

Homo sapiens

Sample Type

specimens

Anatomical Entity

brain

Organ Part

superior parietal cortex

Selected Cell Types

microglial cell

Disease Status (Specimen)

3 disease statuses

Disease Status (Donor)

3 disease statuses

Development Stage

human adult stage

Library Construction Method

3 library construction methods

Nucleic Acid Source

2 nucleic acid sources

Paired End

false, true

File Format

5 file formats

Cell Count Estimate

65.8k

Donor Count

27
bam2 file(s)fastq.gz398 file(s)loom3 file(s)tar1 file(s)xlsx1 file(s)
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