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Developmental cell programs are co-opted in inflammatory skin disease.

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Updated July 19, 2022

We generated a comprehensive atlas of human skin in early prenatal life, in adulthood, and during inflammatory skin disease by profiling the transcriptomes of more than 500,000 single cells. We analyzed human embryonic skin between 7 and 10 post-conception weeks, healthy adult skin surplus from mammoplasty surgery, and skin biopsies from patients affected by atopic dermatitis (AD) and psoriasis, two common inflammatory skin diseases.

Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campusst9@sanger.ac.uk
Fiona M WattCentre for Stem Cells and Regenerative Medicine, King’s College London, Guy’s Hospital Campusfiona.watt@kcl.ac.uk
Muzlifah HaniffaBiosciences Institute, Newcastle Universitym.a.haniffa@newcastle.ac.uk
Gary Reynolds1
Peter Vegh1
James Fletcher1
Elizabeth FM Poyner1
Emily Stephenson1
Issac Goh1
Rachel A Botting1
Ni Huang2
Bayanne Olabi1
Anna Dubois1
David Dixon1
Kile Green1
Daniel Maunder1
Justin Engelbert1
Mirjana Efremova2
Krzysztof Polanski2
Laura Jardine1
Claire Jones1
Thomas Ness1
Dave Horsfall1
Jim McGrath1
Christopher Carey1
Dorin-Mirel Popescu1
Simone Webb1
Xiao-nong Wang1
Ben Sayer1
Jong-Eun Park2
Victor A Negri3
Daria Belokhvostova3
Magnus D Lynch3
David McDonald1
Andrew Filby1
Tzachi Hagai4
Kerstin B Meyer2
Akhtar Husain5
Jonathan Coxhead1
Roser Vento-Tormo2
Sam Behjati2
Steven Lisgo1
Alexandra-Chloé Villani6
Jaume Bacardit7
Philip H Jones2
Edel A O’Toole8
Graham S Ogg9
Neil Rajan1
Nick J Reynolds10
Sarah A Teichmann (Principal Investigator)2
Fiona M Watt (Principal Investigator)3
Muzlifah Haniffa (Principal Investigator)1
1Biosciences Institute, Newcastle University
2Wellcome Sanger Institute, Wellcome Genome Campus
3Centre for Stem Cells and Regenerative Medicine, King’s College London, Guy’s Hospital Campus
4Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University
5Department of Pathology, Royal Victoria Infirmary
6Broad Institute of Harvard and MIT
7School of Computing, Newcastle University
8Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London
9MRC Human Immunology Unit, Oxford Biomedical Research Centre, MRC Weatherall Institute of Molecular Medicine, University of Oxford
10Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust
Ami Day

To reference this project, please use the following link:

https://explore.data.humancellatlas.org/projects/c5f46615-68de-4cf4-bbc2-a0ae10f08243
None
Array Express Accessions:
E-MTAB-8142

Downloaded and exported data is governed by the HCA Data Release Policy and licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). For more information please see our Data Use Agreement.

Atlas

None

Analysis Portals

CZ CELLxGENECZ CELLxGENE
UCSC Cell BrowserUCSC Cell Browser

Project Label

DevelopmentalCellProgramsSkin

Species

Homo sapiens

Sample Type

specimens

Anatomical Entity

skin of body

Organ Part

2 organ parts

Selected Cell Types

7 cell types

Disease Status (Specimen)

3 disease statuses

Disease Status (Donor)

3 disease statuses

Development Stage

human adult stage

Library Construction Method

10x 3' v2

Nucleic Acid Source

single cell

Paired End

false

Analysis Protocol

analysis_protocol

File Format

zip

Cell Count Estimate

7.0k

Donor Count

12
zip1 file(s)