Spatial multi-omic map of human myocardial infarction

Myocardial infarction is a leading cause of mortality worldwide. While advances in the acute treatment have been made, the late-stage mortality is still elevated. We used single-cell gene expression, chromatin accessibility and spatial transcriptomic profiling of different physiological zones and timepoints of human myocardial infarction and human control myocardium to generate an integrative high-resolution map of cardiac tissue remodeling. This approach allowed us to increase spatial resolution of cell-type composition and provide spatially resolved insights into changes of the the cardiac transcriptome and epigenome with identification of distinct cellular zones of injury, repair and remodeling. This study provides an integrative molecular map of human myocardial infarction and represents a reference to advance mechanistic and therapeutic studies of cardiac disease.

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