Spatial multi-omic map of human myocardial infarction
Myocardial infarction is a leading cause of mortality worldwide. While advances in the acute treatment have been made, the late-stage mortality is still elevated. We used single-cell gene expression, chromatin accessibility and spatial transcriptomic profiling of different physiological zones and timepoints of human myocardial infarction and human control myocardium to generate an integrative high-resolution map of cardiac tissue remodeling. This approach allowed us to increase spatial resolution of cell-type composition and provide spatially resolved insights into changes of the the cardiac transcriptome and epigenome with identification of distinct cellular zones of injury, repair and remodeling. This study provides an integrative molecular map of human myocardial infarction and represents a reference to advance mechanistic and therapeutic studies of cardiac disease.
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Analysis Portals
Project Label
myocardialInfarctionSpecies
Homo sapiens
Sample Type
specimens
Anatomical Entity
heart
Organ Part
Selected Cell Types
Unspecified
Disease Status (Specimen)
Disease Status (Donor)
Development Stage
human adult stage
Library Construction Method
Nucleic Acid Source
Paired End
false, trueAnalysis Protocol
atac_seq_processing, cell_annotation_transfer, cellranger_matrix_generation, spaceranger_matrix_generation, spatial_transcriptomics_characterisationFile Format
Cell Count Estimate
12.2kDonor Count
23