Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
Temporal resolution of cellular features associated with a severe COVID-19 disease trajectory is needed for understanding skewed immune responses and defining predictors of outcome. Here, the authors performed a longitudinal multi-omics study using a two-center cohort of 14 patients. They analyzed the bulk transcriptome, bulk DNA methylome, and single-cell transcriptome (>358,000 cells, including BCR profiles) of peripheral blood samples harvested from up to 5 time points. Validation was performed in two independent cohorts of COVID-19 patients.
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Atlas
Analysis Portals
NoneProject Label
LongitudinalMultiomicsCovid19Species
Homo sapiens
Sample Type
specimens
Anatomical Entity
blood
Organ Part
Unspecified
Selected Cell Types
Unspecified
Disease Status (Specimen)
Disease Status (Donor)
Development Stage
human adult stage
Library Construction Method
Nucleic Acid Source
Paired End
false, trueAnalysis Protocol
analysis _protocol_bulk_BCR, analysis _protocol_bulk_RNA, cell_type_analysis_protocol, gene_expression_quantification_protocolFile Format
Cell Count Estimate
358.9kDonor Count
28